Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Computer-assisted analysis of two-dimensional electrophoresis images using an array processor.

D J Potter

    Computers and Biomedical Research, an International Journal
    |August 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A review of the CLIP system for the quantitative analysis of two-dimensional electrophoresis gels.

    Electrophoresis·1990
    Same author

    Neural attrition following limb loss and regeneration in juvenile lobsters.

    Journal of neurobiology·1988
    Same author

    Parallel algorithms for querying data on two-dimensional electrophoresis gels.

    Computers and biomedical research, an international journal·1988
    Same author

    Development of bilateral asymmetry in sensory innervation to lobster claws.

    Brain research·1987
    Same author

    Parallel algorithms for the analysis of two-dimensional electrophoresis gels.

    Computers and biomedical research, an international journal·1986
    Same author

    Myths and facts in end-stage renal disease treatment.

    Arizona medicine·1984
    Same journal

    Wavelet domain nonlinear filtering for evoked potential signal enhancement.

    Computers and biomedical research, an international journal·2001
    Same journal

    Time-frequency analysis of the RT and RR variability to stratify hypertrophic cardiomyopathy patients.

    Computers and biomedical research, an international journal·2001
    Same journal

    Controlled auxotonic twitch in papillary muscle: a new computer-based control approach.

    Computers and biomedical research, an international journal·2001
    Same journal

    Controlling for chance agreement in the validation of medical expert systems with no gold standard: PNEUMON-IA and RENOIR revisited.

    Computers and biomedical research, an international journal·2001
    Same journal

    Artificial neural networks compared to factor analysis for low-dimensional classification of high-dimensional body fat topography data of healthy and diabetic subjects.

    Computers and biomedical research, an international journal·2000
    Same journal

    On the parallelization of linkmap from the LINKAGE/FASTLINK package.

    Computers and biomedical research, an international journal·2000
    See all related articles

    The CLIP4 machine accelerates analysis of 2D electrophoresis gel images using novel, parallelized segmentation and comparison algorithms for high-speed spot matching. This technology offers unprecedented efficiency in gel image processing.

    Area of Science:

    • Biotechnology
    • Computer Science
    • Bioinformatics

    Background:

    • Two-dimensional electrophoresis (2DE) is crucial for protein analysis.
    • Analyzing 2DE gel images is computationally intensive and time-consuming.
    • Existing gel analysis systems lack the speed required for large-scale studies.

    Purpose of the Study:

    • To introduce the CLIP4 machine for high-speed 2DE gel image analysis.
    • To describe novel segmentation and comparison algorithms optimized for parallel processing.
    • To enhance the efficiency and accuracy of protein spot matching in 2DE gels.

    Main Methods:

    • Utilized the CLIP4 machine, a highly parallel computing architecture.
    • Developed an optimized segmentation algorithm leveraging existing methods for parallel execution.

    Related Experiment Videos

  • Implemented a novel comparison algorithm designed for full parallel efficiency.
  • Applied algorithms to simultaneously match all pairs of protein spots between gels.

    • Main Results:

    • The CLIP4 machine demonstrated high-speed processing capabilities for 2DE gel images.
    • Optimized segmentation algorithms efficiently processed gel data.
    • The novel comparison algorithm achieved simultaneous matching of all spot pairs.
    • The system's parallel architecture significantly outperformed conventional machines.

    Conclusions:

    • The CLIP4 machine and its associated algorithms provide a significant advancement in 2DE gel image analysis.
    • High-speed, parallel processing enables more efficient and comprehensive protein profiling.
    • This approach is vital for large-scale proteomic research and biomarker discovery.