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Experimental macular edema after lens extraction.

M O Tso, C Y Shih

    Investigative Ophthalmology & Visual Science
    |May 1, 1977
    PubMed
    Summary
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    Macular edema after cataract surgery may stem from a disrupted blood-retinal barrier. This disruption, particularly in the macula, was observed in rhesus monkeys following lens extraction with vitreous loss.

    Area of Science:

    • Ophthalmology
    • Retinal Science
    • Surgical Complications

    Background:

    • Macular edema is a common complication following cataract extraction.
    • The exact pathogenic mechanisms underlying this condition remain incompletely understood.

    Purpose of the Study:

    • To investigate the pathogenic mechanisms of macular edema after lens extraction.
    • To examine the integrity of the blood-retinal barrier in the macula following cataract surgery.

    Main Methods:

    • Lens extraction was performed on seven eyes of four rhesus monkeys.
    • Ophthalmoscopy, fundus photography, fluorescein angiography, light and electron microscopy, and horseradish peroxidase tracer techniques were employed.
    • Examination focused on the macular and peripheral retinal regions.

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    Main Results:

    • Disruption of the blood-retinal barrier at the retinal vasculature was observed in three of seven eyes.
    • Vitreous loss during lens extraction was associated with blood-retinal barrier disruption.
    • Horseradish peroxidase tracer confirmed barrier breaches in the maculae of affected eyes.
    • The blood-retinal barrier in the peripheral retina remained largely intact.

    Conclusions:

    • Macular edema following lens extraction is attributed to the disruption of the blood-retinal barrier.
    • Both the retinal vasculature and retinal pigment epithelium are implicated levels of barrier disruption.
    • Vitreous loss appears to be a significant factor contributing to this complication.