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Experimental myelin intrusion in the nerve head
Investigative Ophthalmology & Visual Science
|May 1, 1977
Summary
Traumatic optic nerve lesions can cause myelin to enter the optic disc. This myelin is visible initially but is later obscured by hemorrhage and tissue repair.
Area of Science:
- Ophthalmology
- Neuroscience
- Pathology
Background:
- Traumatic optic nerve injuries are a significant cause of vision loss.
- The behavior of myelin following such injuries is not fully understood.
Purpose of the Study:
- To investigate the clinical and histopathologic changes associated with myelin intrusion into the optic papilla and peripapillary region after traumatic optic nerve lesions.
Main Methods:
- Nine monkey eyes underwent hemostat compression of the optic nerve near the globe.
- Eyes were studied clinically and histopathologically over periods up to 28 days.
Main Results:
- Ophthalmoscopic examination revealed initial myelin intrusion, followed by hemorrhage.
- Histopathology confirmed myelin presence within the first two weeks, subsequently masked by hemorrhage and gliosis.
- Myelinolytic reactions were observed in the optic nerve.
Conclusions:
- Myelin intrusion into the optic nerve head can occur following traumatic injury.
- Hemorrhage and subsequent gliosis obscure the presence of myelin over time.
- Understanding these changes is crucial for diagnosing and managing optic nerve trauma.