Related Experiment Video

Updated: Jun 18, 2026

Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

Celebrating Ulrik Ringborg: Multi-Omics-Based Patient Stratification for Precision Cancer Treatment

Maria-Veronica Teleanu1,2,3, Annika Schneider4,5, Claudia R Ball6,7,8,9

  • 1Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Biomolecules
|May 28, 2025
PubMed

Insights

Precision oncology uses advanced tumor profiling to personalize cancer care. Multi-omics data aids in patient stratification and developing new targeted therapies for better outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Diagnostics

Background:

  • Precision oncology is a standard of care for cancer patients.
  • Technological advancements have decreased tumor profiling costs, increasing access to molecular diagnostics.
  • Drug development is advancing targeted therapies, but not all patients respond, and targets remain limited.

Purpose of the Study:

  • To review omics technologies in clinical settings for understanding tumor biology.
  • To optimize patient stratification for targeted cancer treatments.
  • To discuss precision oncology trials and the use of multi-omics data in molecular tumor boards.

Main Methods:

  • Review of current omics technologies used in clinical settings.
  • Analysis of precision oncology trials.
  • Case studies on multi-omics data utilization in molecular tumor boards.

Main Results:

  • Omics technologies deepen the understanding of tumor biology.
  • Multi-omics data aids in optimizing patient stratification for targeted therapies.
  • Molecular tumor boards effectively integrate multi-omics data for treatment decisions.

Conclusions:

  • Precision oncology requires continuous advancement in omics technologies and drug development.
  • Multi-omics data integration is crucial for effective patient stratification and personalized treatment.
  • Future research should focus on expanding molecular targets and improving treatment response rates.
Keywords:
molecular profilingpatient stratificationprecision oncology

More Related Videos

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Strategy for Biobanking of Ovarian Cancer Organoids: Addressing the Interpatient Heterogeneity across Histological Subtypes and Disease Stages08:26

Strategy for Biobanking of Ovarian Cancer Organoids: Addressing the Interpatient Heterogeneity across Histological Subtypes and Disease Stages

Published on: February 23, 2024

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...