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Nav1.8 and Chronic Pain: From Laboratory Animals to Clinical Patients
1Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Biomolecules
|May 28, 2025
Summary
Nav1.8 channels, involved in chronic pain, show potential as therapeutic targets. Research highlights Nav1.8
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Nav1.8 channels, encoded by SCN10A, are crucial voltage-gated sodium channels in dorsal root ganglion (DRG) sensory neurons.
- Gain- or loss-of-function variants in Nav1.8 are linked to chronic pain or pain insensitivity in patients.
- Nav1.8's role in chronic pain is supported by animal models, positioning it as a potential therapeutic target.
Purpose of the Study:
- To review recent clinical and laboratory findings on Nav1.8's involvement in chronic pain.
- To discuss the discrepancies between preclinical and clinical studies of sodium channel targets for pain.
- To provide insights for future Nav1.8 research, considering Nav1.7's challenges.
Main Methods:
- Literature review of clinical findings in patients with pain variants.
- Analysis of data from animal models of chronic pain involving Nav1.8.
- Comparative analysis of Nav1.8 and Nav1.7 channel functions in DRG neuronal excitability.
Main Results:
- Nav1.8 variants correlate with chronic pain conditions.
- Nav1.8 is implicated in animal models of chronic pain.
- Nav1.7 drug development faces challenges due to clinical-preclinical discrepancies.
Conclusions:
- Nav1.8 represents a promising target for chronic pain treatment.
- Understanding DRG neuronal excitability is key to addressing chronic pain.
- Further investigation into Nav1.8 is warranted, informed by Nav1.7's clinical translation issues.
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