Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foxe1 deficiency impairs thyroid fate while supporting lung differentiation.

EMBO reports·2026
Same author

The role of Nrf2 in thyroid maturation and hormone synthesis in vertebrate models.

Life science alliance·2026
Same author

Human thyroid organoids: tools for understanding thyroid diseases and development.

Nature reviews. Endocrinology·2026
Same author

Pyriproxyfen, villain or good guy? A brief review.

Archives of endocrinology and metabolism·2025
Same author

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids.

Oncogene·2023
Same author

Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration.

Endocrinology·2023
Same journal

Correction: Reis et al. Bioinks Enriched with ECM Components Obtained by Supercritical Extraction. <i>Biomolecules</i> 2022, <i>12</i>, 394.

Biomolecules·2026
Same journal

Correction: Kim, K.-H.; Yoo, B.C. Gintonin as a Lysophosphatidic Acid-Enriched GPCR Ligand System: Molecular Architecture and Receptor Pharmacology in <i>Panax ginseng</i>. <i>Biomolecules</i> 2026, <i>16</i>, 465.

Biomolecules·2026
Same journal

Correction: Bastyte et al. The Association of Vitamin D Receptor Gene Polymorphisms with Vitamin D, Total IgE, and Blood Eosinophils in Patients with Atopy. <i>Biomolecules</i> 2024, <i>14</i>, 212.

Biomolecules·2026
Same journal

AtHSPR Plays a Positive Role in Arabidopsis Resistance Against <i>Pseudomonas syringae</i> pv. <i>tomato</i> DC3000 by Interacting with TOP1.

Biomolecules·2026
Same journal

CYTH4 Facilitates Renal Cell Carcinoma via Enhancing Proliferation and Likely Immune Evasion.

Biomolecules·2026
Same journal

Integrated Immune-Gut Profiling Identifies an Exploratory Pediatric Inflammatory Intestinal Profile Associated with Food-Specific IgG Reactivity.

Biomolecules·2026
See all related articles

Related Experiment Video

Updated: Apr 2, 2026

Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids
10:40

Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids

Published on: June 5, 2020

18.2K

Functional Thyroid Organoids-Powerful Stem Cell-Derived Models in Basic and Translational Research.

Meghna Parakkal Shankar1, Alessandra Boggian1, Daniela Aparicio-Quiñonez1

  • 1Institute of Jacques-Dumont Interdisciplinary Research in Molecular Human Biology (Jacques-Dumont IRIBHM), Université Libre de Bruxelles, 1070 Brussels, Belgium.

Biomolecules
|May 28, 2025
PubMed
Summary
This summary is machine-generated.

Thyroid organoids, derived from stem cells, mimic the thyroid gland for studying development and diseases. These models offer potential for personalized medicine and advancing thyroid research.

Keywords:
congenital hypothyroidismdisease modelingendocrine disruptorsregenerative therapystem cellsthyroid developmentthyroid diseasesthyroid organoidsthyroid transplantation

More Related Videos

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses
08:36

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses

Published on: October 24, 2019

11.8K
Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue
07:31

Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Published on: May 26, 2023

6.4K

Related Experiment Videos

Last Updated: Apr 2, 2026

Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids
10:40

Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids

Published on: June 5, 2020

18.2K
Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses
08:36

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses

Published on: October 24, 2019

11.8K
Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue
07:31

Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Published on: May 26, 2023

6.4K

Area of Science:

  • Endocrinology and Stem Cell Biology
  • Developmental Biology and Disease Modeling

Background:

  • Thyroid organoids are 3D in vitro models derived from stem cells.
  • They recapitulate key thyroid gland structures and functions, including hormone production and TSH response.

Purpose of the Study:

  • To review recent advancements in thyroid organoid generation and applications.
  • To discuss their utility in understanding thyroid development and disease mechanisms.
  • To explore their potential in personalized medicine and translational research.

Main Methods:

  • Generation of thyroid organoids from pluripotent stem cells (PSCs) and adult tissues.
  • Utilizing these organoids to model thyroid development and diseases.
  • Analyzing genetic, functional, and inflammatory characteristics of modeled diseases.

Main Results:

  • Thyroid organoids successfully mimic thyroid gland structure and function.
  • They enable the study of congenital hypothyroidism, Graves' disease, and Hashimoto's thyroiditis.
  • Organoids provide a platform for dissecting disease mechanisms and testing therapies.

Conclusions:

  • Thyroid organoids are powerful tools for thyroid research and disease modeling.
  • They hold significant promise for advancing our understanding of thyroid physiology and pathology.
  • Further optimization is needed for their full potential in translational research.