Glucose tolerance in granuloma annulare

Area of Science:

• Dermatology
• Endocrinology
• Metabolic Research

Background:

• Granuloma annulare (GA) is a benign inflammatory skin condition.
• Previous studies suggest a potential link between GA and glucose intolerance.

Observation:

• Twenty-one patients with GA underwent oral and intravenous glucose tolerance tests (GTT).
• Obese patients and those with frank diabetes mellitus were excluded from the primary analysis.
• GA patients were compared to 14 age- and weight-matched controls.

Findings:

• GA patients exhibited significantly higher fasting plasma glucose, 2-h plasma glucose, and glucose curve area during oral GTT compared to controls.
• Elevated 1-h serum insulin and insulin curve area were also observed in GA patients during oral GTT.
• Intravenous GTT indicated an intact immediately releasable insulin pool but higher fasting plasma glucose and glucose curve area in GA patients.

Implications:

• The findings suggest impaired glucose tolerance in patients with Granuloma annulare.
• Evidence points towards the presence of insulin resistance in individuals with GA.
• This association warrants further investigation into the underlying mechanisms and clinical significance.