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Associations of Thyroid and Parathyroid Hormones with Arterial Stiffness in Emergency Department Patients: A

Roman Brock1, Andrea Kornfehl1, Julia Oppenauer1

  • 1Department of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria.

Medicina (Kaunas, Lithuania)
|May 28, 2025
PubMed

Insights

Elevated thyroid and parathyroid hormone levels are linked to increased arterial stiffness in emergency patients. This highlights the importance of endocrine evaluation for cardiovascular risk assessment.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Emergency Medicine

Background:

  • Cardiovascular diseases are common in emergency settings.
  • Arterial stiffness, measured by carotid-femoral pulse wave velocity (cfPWV), predicts cardiovascular risk.
  • Endocrine factors are implicated in arterial stiffness, but mechanisms require further study.

Purpose of the Study:

  • To investigate the association between endocrine parameters and arterial stiffness (cfPWV).
  • Specifically examined thyroid hormones, parathyroid hormone, calcium, phosphate, and vitamin D.

Main Methods:

  • Prospective enrollment of 827 adult patients in a tertiary care emergency department.
  • Non-invasive measurement of cfPWV.
  • Assessment of relevant hormone and mineral levels.

Main Results:

  • Higher parathyroid hormone levels correlated significantly with increased cfPWV (p < 0.001).
  • Elevated TSH (thyroid-stimulating hormone) levels were also associated with greater arterial stiffness (p = 0.03).
  • No significant association was found for calcium, inorganic phosphate, or 25-hydroxyvitamin D.

Conclusions:

  • Thyroid and parathyroid hormones are associated with arterial stiffness in emergency department patients.
  • Consider endocrine workup for patients with comorbidities and advanced age at risk for arterial stiffness.
  • Further research is needed to clarify the role of endocrinology in arterial stiffness and its emergency medicine implications.

Keywords:
arterial stiffnessparathyroid hormonepulse wave velocitythyroid dysfunctionvascular calcificationvitamin D

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