Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

371
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
371
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

173
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
173
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

225
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
225
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

804
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
804
Vitamins01:30

Vitamins

1.0K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulses and Cancer Outcomes: A Scoping Review of Human Studies on Risk Reduction.

Nutrients·2026
Same author

Cardiometabolic associations of SGLT-2 inhibitors on epicardial adiposity and left ventricular function in type 2 diabetes mellitus with coronary artery disease: insights from Malaysian EpiCAD study.

Scientific reports·2026
Same author

Therapeutic potential of combination medicinal mushrooms (NevG) in ischemic stroke: correlating motor function, cognitive recovery, and hippocampal integrity in MCAO rats.

Frontiers in pharmacology·2026
Same author

Physicochemical Analysis and Digestive Enzymes Inhibition of a Selected Malaysian <i>Apis cerana</i> Honey.

Foods (Basel, Switzerland)·2025
Same author

Green synthesis and functional evaluation of zinc oxide nanoparticles from red dragon fruit peel.

Scientific reports·2025
Same author

Antioxidant and Hepatoprotective Effects of <i>Moringa oleifera</i>-mediated Selenium Nanoparticles in Diabetic Rats.

F1000Research·2025

Related Experiment Video

Updated: Sep 20, 2025

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

28.9K

Exploring the Link Between Vitamin K and Depression: A Systematic Review.

Mohamad Hisham Hashim1, Nik Nasihah Nik Ramli1, Siti Nur Atiqah Zulaikah Nasarudin1

  • 1School of Graduate Studies, Management and Science University, Shah Alam 40100, Malaysia.

Medicina (Kaunas, Lithuania)
|May 28, 2025
PubMed
Summary

Emerging research suggests vitamin K may impact mood regulation. This review found a potential inverse association between vitamin K levels and depressive symptoms, though more research is needed.

Keywords:
depressionneuroinflammationosteocalcinoxidative stressvitamin K

More Related Videos

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

193
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

825

Related Experiment Videos

Last Updated: Sep 20, 2025

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

28.9K
Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

193
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

825

Area of Science:

  • Neuroscience
  • Nutritional Psychiatry
  • Biochemistry

Background:

  • Depression is a complex disorder linked to inflammation, oxidative stress, and metabolic dysfunction.
  • Vitamin K, traditionally known for coagulation and bone health, is increasingly explored for its neurobiological roles.
  • Potential links between vitamin K and mood regulation are emerging.

Purpose of the Study:

  • To systematically review the association between vitamin K and depressive symptoms.
  • To explore potential mechanisms underlying this association.

Main Methods:

  • Systematic literature search across major databases (PubMed, Scopus, etc.) following PRISMA 2020 guidelines.
  • Included human and animal studies assessing vitamin K status (dietary intake, serum levels) and depression outcomes.
  • Analyzed eleven observational studies, one RCT, and two preclinical studies.

Main Results:

  • Most observational studies indicated an inverse relationship between vitamin K levels/intake and depressive symptoms.
  • A small RCT showed modest depression score improvement with vitamin K2 supplementation in PCOS women.
  • Preclinical studies reported behavioral benefits and reduced oxidative stress with vitamin K2.

Conclusions:

  • Preliminary evidence suggests vitamin K may play a role in depression pathways.
  • Current evidence is limited by study design (e.g., cross-sectional) and lack of depression-specific models.
  • Further research is needed to investigate mechanisms like inflammation reduction, oxidative stress modulation, and vitamin K-dependent protein signaling in depression.