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A liver-function test using 15N-labelled ammonium chloride.

K Jung, K Hirschberg, H Faust

    European Journal of Nuclear Medicine
    |January 1, 1985
    PubMed
    Summary
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    This study introduces a new method to assess liver function by measuring 15N-ammonia and 15N-urea in urine after oral ammonia loading. The test effectively distinguishes liver disease patients from healthy individuals.

    Area of Science:

    • Biochemistry
    • Hepatology
    • Medical Diagnostics

    Background:

    • Liver malfunction significantly impairs urea synthesis and ammonia detoxification.
    • Ammonia loading exacerbates these metabolic disturbances, highlighting the need for sensitive diagnostic tools.

    Purpose of the Study:

    • To evaluate a novel method for assessing liver functional state using isotope analysis.
    • To determine the efficacy of oral 15NH4Cl loading and urinary 15N analysis in diagnosing liver disease.

    Main Methods:

    • Oral administration of 15NH4Cl to subjects.
    • Analysis of urinary 15N-urea and 15N-ammonia using emission spectrometry.
    • Calculation of the ratio of excess 15N-ammonia to 15N-urea excreted within 3 hours.

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    Main Results:

    • Patients with liver disease exhibited significantly different urinary 15N-ammonia/15N-urea ratios compared to healthy controls.
    • The method demonstrated effectiveness in differentiating between diseased and healthy liver states.

    Conclusions:

    • The 15NH4Cl loading test combined with urinary 15N analysis is a sensitive and effective method for assessing liver function.
    • Absorption disturbances associated with liver disease do not compromise the diagnostic accuracy of this method.