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Related Experiment Videos

Growth in Cushing syndrome.

R Voutilainen, S Leisti, J Perheentupa

    European Journal of Pediatrics
    |July 1, 1985
    PubMed
    Summary

    Cushing syndrome in children often presents with growth deceleration and weight gain before characteristic symptoms appear. Early recognition of these growth changes is crucial for timely diagnosis and treatment.

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    Area of Science:

    • Pediatric Endocrinology
    • Growth Disorders
    • Endocrine Surgery

    Background:

    • Cushing syndrome, characterized by excessive cortisol, can impact childhood growth.
    • Typical cushingoid features are not always present in pediatric cases.
    • Growth deceleration and weight gain are consistent indicators.

    Purpose of the Study:

    • To analyze pre- and post-operative growth patterns in children with Cushing syndrome.
    • To identify key indicators for early diagnosis of pediatric Cushing syndrome.
    • To compare growth recovery after different surgical treatments for Cushing's disease.

    Main Methods:

    • Analysis of longitudinal growth and relative weight in eight children with Cushing syndrome.
    • Review of treatment outcomes following bilateral adrenalectomy and transsphenoidal pituitary adenectomy.
    • Correlation of growth changes with the onset of hypercortisolism.

    Main Results:

    • Abnormal growth deceleration and increased relative weight were constant findings.
    • Growth changes preceded diagnosis by 0.2-5.1 years, sometimes occurring before or concurrently with weight gain.
    • A potential for better growth recovery was observed after pituitary adenectomy compared to adrenalectomy.

    Conclusions:

    • Growth deceleration and weight gain are critical early signs of Cushing syndrome in children, even without typical cushingoid features.
    • Recognizing these growth patterns can prompt earlier diagnosis of pediatric hypercortisolism.
    • Transsphenoidal pituitary adenectomy may offer superior growth recovery outcomes for Cushing's disease compared to bilateral adrenalectomy.

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