Monocyte to HDL cholesterol ratio predicts obesity-associated cardiac dysfunction

Area of Science:

• Cardiology
• Metabolic Syndrome
• Inflammation Biology

Background:

• Rising obesity rates pose significant risks for cardiac dysfunction.
• Obesity-associated cardiac issues present a major public health challenge.
• Identifying reliable predictive markers for cardiac dysfunction is crucial.

Purpose of the Study:

• To identify novel lipid and inflammatory markers for predicting obesity-associated cardiac dysfunction.
• To evaluate the predictive power of the monocyte to HDL-C ratio (MHR) for left ventricular ejection fraction (LVEF) decline.
• To elucidate the role of MHR in obesity-related cardiac systolic dysfunction.

Main Methods:

• Retrospective analysis of clinical data from 5648 cardiac disease patients.
• Statistical analysis including univariate and multivariate regression models.
• Mediation analysis to explore the relationship between MHR and cardiac function.

Main Results:

• Both high-density lipoprotein cholesterol (HDL-C) levels and monocyte counts were associated with impaired LVEF.
• The monocyte to HDL-C ratio (MHR) demonstrated a stronger association with LVEF decline than individual markers.
• Mediation analysis confirmed MHR's role in obesity-associated cardiac systolic dysfunction.

Conclusions:

• The MHR is a superior predictor of obesity-associated cardiac systolic dysfunction compared to routine metabolic and inflammatory markers.
• MHR offers a valuable tool for assessing cardiac risk in obese individuals.
• Further research into MHR's clinical applications in cardiovascular disease management is warranted.