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Impact of Polygenic Interactions With Anticholinergic Burden on Cognition and Brain Structure in Psychosis Spectrum

Lusi Zhang1, Elena I Ivleva1, David A Parker1

  • 1Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop).

The American Journal of Psychiatry
|May 28, 2025
PubMed
Abstract

Keywords:
Anticholinergic BurdenBrain StructureCognition/Learning/MemoryGenetics/GenomicsNeuroimagingSchizophrenia Spectrum and Other Psychotic Disorders

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