Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise Stress Test01:26

Exercise Stress Test

520
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
520
Dysrhythmias V: Evaluating Dysrhythmias01:30

Dysrhythmias V: Evaluating Dysrhythmias

123
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
123
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

1.1K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
1.1K
Electrocardiogram01:29

Electrocardiogram

3.3K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
3.3K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

355
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
355
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

67
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
67

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vericiguat therapy reduces arrhythmic events in heart failure patients with cardiac implantable electronic devices.

Heart rhythm·2026
Same authorSame journal

[Ranolazine: established indications and emerging therapeutic potential].

Giornale italiano di cardiologia (2006)·2026
Same authorSame journal

[Green paper ANMCO: Environmental sustainability in cardiology: a shared commitment of healthcare professionals].

Giornale italiano di cardiologia (2006)·2026
Same author

ANMCO position paper E-health integration in cardiology clinical care framework.

European heart journal supplements : journal of the European Society of Cardiology·2026
Same author

Position paper ANMCO in collaboration with Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P): 'the management of hospital discharge'.

European heart journal supplements : journal of the European Society of Cardiology·2026
Same author

ANMCO position paper: ANMCO general assembly 2024-the role of the cardiologist in the management of cardiovascular chronicity.

European heart journal supplements : journal of the European Society of Cardiology·2026

Related Experiment Video

Updated: Sep 20, 2025

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.6K

[Heart, sport, and genetic testing].

Stefania Angela Di Fusco1, Silvia Castelletti2, Cristina Chimenti3

  • 1U.O.C. Cardiologia Clinica e Riabilitativa, Presidio Ospedaliero San Filippo Neri - ASL Roma 1, Roma.

Giornale Italiano Di Cardiologia (2006)
|May 28, 2025
PubMed
Summary

Genetic testing aids in diagnosing hereditary cardiovascular diseases in athletes. Careful interpretation is crucial to avoid misdiagnosis and career-ending disqualifications.

More Related Videos

Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System
02:47

Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System

Published on: May 12, 2023

1.5K
Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

20.6K

Related Experiment Videos

Last Updated: Sep 20, 2025

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.6K
Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System
02:47

Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System

Published on: May 12, 2023

1.5K
Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

20.6K

Area of Science:

  • Cardiovascular Genetics
  • Sports Cardiology
  • Clinical Diagnostics

Background:

  • Genetic tests are valuable for diagnosing hereditary cardiovascular conditions like cardiomyopathies, arrhythmias, and aortic diseases.
  • Diagnosing these conditions in athletes is complex due to physiological adaptations from intense training that can mimic disease on ECG and echocardiograms.
  • Inappropriate genetic testing or interpretation can lead to unwarranted athlete disqualification, impacting careers and mental well-being.

Purpose of the Study:

  • To review the role of genetic testing in differentiating athlete's heart adaptations from hereditary pathologies.
  • To discuss the impact of genetic test results on prognostic stratification in diagnosed athletes.
  • To equip clinicians with tools for deciding when to recommend genetic testing in ambiguous cases.

Main Methods:

  • Literature review focusing on genetic testing in athletes.
  • Analysis of genetic testing's utility in cardiomyopathies, channelopathies, and aortic diseases.
  • Examination of clinical and instrumental findings (ECG, imaging) in conjunction with genetic data.

Main Results:

  • Genetic testing can aid in early diagnosis and management of hereditary cardiovascular diseases in athletes.
  • Distinguishing adaptive cardiac changes from inherited conditions is a key application.
  • Genetic results influence prognostic stratification for athletes with confirmed diagnoses.

Conclusions:

  • Genetic testing is a valuable tool in sports cardiology when integrated with clinical and imaging data.
  • Multidisciplinary interpretation is essential to ensure appropriate use and avoid adverse outcomes for athletes.
  • Guidelines are needed to optimize the application of genetic testing in athletic populations.