[Morphobiophysical parallels in assessing the hepatotropic action of nitrosodimethylamine]

On the third day after a single administration of nitrosodimethylamine (30 mg/kg) to white rats histochemistry reveals the greatest injury to the liver parenchyma. This correlates with a reduction in relative strength of intercellular contacts, an increase in relative strength of the membranes, and an elevation of the membrane potential during liver tissue survival in vitro. The latter fact can be explained, at any rate partially, by the lowering of the activity of cytoplasmic ATPase which competes with electrogenic Na+. K+-ATPase for ATP.