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[Effect of diazepam on interference processes].

I M Vinitskiĭ, N I Dubrovina, R Iu Il'iuchenok

Farmakologiia I Toksikologiia

|July 1, 1985

Summary

Diazepam enhances inhibitory effects in conditioned reflexes, demonstrating its role in behavioral interference. This suggests the GABAergic amygdalofugal system is key to these interactions.

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Area of Science:

Neuroscience
Behavioral Pharmacology
Neurophysiology

Background:

Behavioral interference occurs when one conditioned reflex disrupts another.
The amygdala plays a role in modulating neural pathways involved in learning and memory.
GABAergic systems are known to mediate inhibitory neurotransmission.

Purpose of the Study:

To investigate the effect of diazepam on behavioral interference between two conditioned reflexes.
To explore the electrophysiological mechanisms underlying diazepam's modulatory effects on amygdaloid pathways.

Main Methods:

Experimental behavioral training involving two rapidly sequential conditioned reflexes.
Intraperitoneal injection of diazepam (2 mg/kg) 30 minutes prior to training.
Electrophysiological analysis of neuronal responses in the central gray matter following amygdaloid stimulation.

Main Results:

Diazepam (2 mg/kg) potentiated the inhibitory effect of a defensive conditioned reflex over a drinking conditioned reflex.
Electrophysiological recordings showed diazepam induced prolonged and pronounced inhibition of neuronal excitatory responses.
These inhibitory effects were observed in response to electrocutaneous stimulation after conditioning stimulation of the amygdala.

Conclusions:

Diazepam administration enhances behavioral interference, specifically augmenting inhibitory processes.
The findings suggest that inhibitory processes mediated by the GABAergic amygdalofugal system are fundamental to the observed interference.
This research provides insight into the neurobiological underpinnings of conditioned reflex interactions and drug-induced modulation.

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