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Sesquiterpenes with anti-inflammatory activity from the stems and branches of Melicope patulinervia

Sai Li^1,2, En-Lian Du^1,2, Qi Gong³

¹School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Journal of Asian Natural Products Research

|May 28, 2025

Abstract:

Five new sesquiterpenes comprising three zieranes, melicopatulones A-C (1-3) and two guaianes, melicopatulones D-E (5-6), were isolated from the stems and branches of Melicope patulinervia, together with melicodenones B (4), C (7) and D (8). Their structures with absolute configurations were elucidated on the basis of analysis of MS, NMR, and TDDFT-ECD calculations. Sesquiterpenes 1, 2 and 6 exhibited significant inhibitory effect at 10 µM on lipopolysaccharide-induced NO production in BV-2 microglial cells.

Keywords:

Melicope patulinervia Rutaceae anti-inflammation guaiane-type sesquiterpenes zierane-type sesquiterpenes

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