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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophils in chronic obstructive pulmonary disease
Marco Vanetti1,2, Dina Visca3,4, Francesco Ardesi4
1Department of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Via Crotto Roncaccio 16, Tradate 12049, Italy.
Therapeutic Advances in Respiratory Disease
|May 28, 2025
Summary
A subset of Chronic Obstructive Pulmonary Disease (COPD) patients exhibit eosinophilic inflammation, impacting disease progression and treatment. Identifying eosinophil levels in blood and sputum is key for targeted therapies in COPD management.
Area of Science:
- Pulmonology
- Immunology
Background:
- Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease characterized by airflow limitation and inflammation.
- While traditionally linked to neutrophilic inflammation, a significant subset of COPD patients (20-40%) show elevated eosinophils.
Purpose of the Study:
- To comprehensively review the role of eosinophils in COPD.
- To analyze eosinophils as biomarkers in blood and sputum for COPD.
- To evaluate the eosinophilic COPD phenotype as a treatable trait.
Main Methods:
- Narrative review of existing literature.
- Evaluation of prevalence data for eosinophilic inflammation in COPD.
- Analysis of different blood and sputum eosinophil thresholds.
- Review of evidence for biological target therapy in eosinophilic COPD.
Main Results:
- Eosinophilic inflammation plays a crucial role in a subset of COPD patients.
- Blood and sputum eosinophil counts can serve as important biomarkers.
- Eosinophilic COPD phenotype is increasingly recognized as a treatable trait.
Conclusions:
- Eosinophil-driven inflammation is a key feature in a subset of COPD patients.
- Biomarker identification of eosinophilic COPD can guide therapeutic strategies.
- Targeted biological therapies show promise for treating eosinophilic COPD.
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