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Risk of Hematologic Malignancies in Patients With Acute Myocardial Infarction: A Nationwide Population-Based Cohort

Seug Yun Yoon1, Mina Kim2, Hoseob Kim2

  • 1Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.

JACC. Cardiooncology
|May 28, 2025
PubMed

Insights

Patients who experienced acute myocardial infarction (AMI) have a significantly higher risk of developing hematologic malignancies. This study highlights the need for vigilance regarding cancer development in AMI survivors.

Area of Science:

  • Cardiology
  • Hematology
  • Oncology

Background:

  • Acute myocardial infarction (AMI) and cancer are major global causes of mortality.
  • The link between AMI and hematologic malignancies is not well-established.

Purpose of the Study:

  • To investigate the association between AMI and the subsequent risk of developing hematologic malignancies.
  • To quantify the risk of hematologic malignancies in patients with a history of AMI.

Main Methods:

  • A retrospective cohort study utilized data from the Korean National Health Insurance claims database.
  • Included 103,686 patients with AMI and 103,686 matched controls without AMI or hematologic malignancies.
  • Gray's competing risk regression model was used to calculate hazard ratios (HRs).

Main Results:

  • The AMI group showed a higher incidence rate of hematologic malignancies (1.21 per 1,000 person-years) compared to the control group (0.93 per 1,000 person-years).
  • Patients with AMI had a significantly increased risk of hematologic malignancy (HR: 1.49; 95% CI: 1.31-1.69).
  • Sensitivity analyses confirmed these findings.

Conclusions:

  • A history of acute myocardial infarction is associated with an elevated risk of developing hematologic malignancies.
  • These findings emphasize the importance of monitoring for hematologic malignancies in patients with AMI.
Abstract

Keywords:
acute coronary syndromebi-directional cardio-oncologyepidemiologyhematologic malignancymyocardial infarctionoutcomesreverse cardio-oncology

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