Antihyperuricemia Bioactive Substances Derived from Marine Organisms

Hyperuricemia is a metabolic disorder attributed to dysregulated purine metabolism or insufficient uric acid excretion. With a high incidence rate and comorbidities burden, hyperuricemia brings enormous pressure to society and attracts much attention nowadays. Though several urate-lowering drugs (including xanthine oxidase inhibitors, uricosuric drugs, and recombinant uricase) are available in clinical practice, their use is often limited due to serious side effects or contraindications. The development of novel urate-lowering drugs and functional foods is in the spotlight. Regarded as an important source of bioactive substances, marine organisms, including seaweeds, animals, and microorganisms, have yielded a large number of bioactive substances with novel structures and unique pharmacological activities. Up to the present, numerous marine organisms-derived bioactive substances have shown potential in combating hyperuricemia. Thus, this review discusses the antihyperuricemia substances derived from marine organisms and summarizes their antihyperuricemia pharmacological properties, with the aim of providing new insights for the development of antihyperuricemia drugs or functional foods from marine organism resources.