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Related Concept Videos

Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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The prognostic factors and treatment patterns of the first recurrence of retroperitoneal liposarcoma.

Yoshiyuki Matsui1,2,3,4,5,6, Shintaro Iwata7,8,9,10,11,12, Konosuke Moritani7,8,9,10,11,12

  • 1Department of Urology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. yomatsui@ncc.go.jp.

International Journal of Clinical Oncology
|May 28, 2025
PubMed
Summary

Recurrence-free survival (RFS) and neutrophil-to-lymphocyte ratio (NLR) at recurrence are key factors influencing treatment and outcomes for retroperitoneal liposarcoma (LPS) patients. These indicators help guide therapeutic decisions and predict prognosis after initial surgery.

Keywords:
Active surveillanceChemotherapyFirst recurrenceRadiationRetroperitoneal liposarcomaSurgery

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Research

Background:

  • Retroperitoneal liposarcoma (LPS) is a rare soft tissue sarcoma.
  • Understanding prognostic factors and treatment patterns at recurrence is crucial for patient management.

Purpose of the Study:

  • To identify prognostic factors for retroperitoneal liposarcoma (LPS) at first recurrence.
  • To analyze treatment patterns employed at the time of first recurrence.

Main Methods:

  • Retrospective analysis of medical records from 150 patients with primary retroperitoneal LPS.
  • Focus on 94 patients experiencing local or distant recurrence.
  • Evaluation of prognostic factors and treatment approaches.

Main Results:

  • Treatment options at recurrence included surgery, radiation, chemotherapy, active surveillance, and supportive care.
  • Well-differentiated primary tumors correlated with better overall survival (OS).
  • Shorter recurrence-free survival (RFS), smaller recurrent tumors, and high neutrophil-to-lymphocyte ratio (NLR) at recurrence were linked to poorer OS.
  • Tumor differentiation changed in 29.2% of surgically treated recurrent cases, predicted by RFS.
  • NLR at recurrence and treatment delay were significant prognostic factors for surgically treated patients.

Conclusions:

  • Recurrence-free survival (RFS), treatment timing, initial tumor differentiation, and recurrence characteristics guide treatment decisions.
  • RFS may predict changes in tumor differentiation.
  • Neutrophil-to-lymphocyte ratio (NLR) at recurrence and treatment waiting period are vital prognostic indicators for surgically treated patients.