An overview on cardiac regeneration revolution: exploring the promise of stem cell therapies

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Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
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Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

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Parisa Noorabadi1, Venus Shahabi Rabori2, Sara Jamali3

  • 1Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Molecular Biology Reports
|May 28, 2025
PubMed

Insights

Stem cell therapies offer a promising avenue for cardiac regeneration, aiming to repair heart damage from myocardial infarction and heart failure. Further research is needed to overcome challenges and translate these innovative treatments into clinical practice.

Area of Science:

  • Regenerative Medicine
  • Cardiology
  • Stem Cell Biology

Background:

  • Cardiovascular diseases (CVDs) are the leading cause of global mortality.
  • Myocardial infarction (MI) and heart failure (HF) present significant clinical challenges due to the heart's limited regenerative capacity.
  • Stem cell-based therapies are being explored as a novel strategy for cardiac regeneration.

Purpose of the Study:

  • To provide a comprehensive overview of stem cell therapies for cardiac regeneration.
  • To discuss molecular mechanisms, cell types, delivery methods, and clinical advancements.
  • To highlight challenges and future directions in the field.

Main Methods:

  • Review of current literature on stem cell therapies for cardiac regeneration.
  • Analysis of molecular signaling pathways (NOTCH, PI3K/Akt, Wnt/β-catenin, Hippo/YAP, MAPK) involved in cardiac repair.
  • Discussion of various stem cell types (MSCs, CPCs, iPSCs, ESCs) and delivery techniques.

Main Results:

  • Stem cell therapies promote cardiac repair through cell replacement and paracrine mechanisms.
  • Key signaling pathways regulate cardiomyocyte proliferation, angiogenesis, fibrosis, and inflammation.
  • Preclinical studies show promise, but clinical outcomes are inconsistent.

Conclusions:

  • Stem cell therapy holds significant potential for treating heart disease and heart failure.
  • Challenges include low cell retention, immune rejection, and variable clinical efficacy.
  • Advancements in genetic engineering and delivery methods are crucial for improving therapeutic outcomes.

Keywords:
Cardiac diseasesCardiac regenerationCell therapyStem cell

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