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Updated: Aug 1, 2026
12:37
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Summary
Pityriasis versicolor susceptibility is not due to single gene defects but likely multifactorial inheritance. Genetic factors contribute an estimated 22.2% heritability in first-degree relatives.
Area of Science:
- Dermatology
- Medical Genetics
- Population Genetics
Background:
- Pityriasis versicolor is a common superficial fungal infection.
- Understanding the inheritance pattern of pityriasis versicolor is crucial for genetic counseling and management.
Purpose of the Study:
- To investigate the inheritance pattern of pityriasis versicolor.
- To determine if pityriasis versicolor follows single gene defects or multifactorial inheritance.
Main Methods:
- A study involving 300 patients (168 males, 132 females) with pityriasis versicolor.
- Data collection through structured questionnaires and examination of relatives.
- Pedigree construction and segregation analysis utilizing population genetics principles.
Main Results:
- Collected data indicated genetic susceptibility inconsistent with single gene defects.
- Findings align with the criteria for multifactorial (genetic-environmental) inheritance.
- Estimated heritability was 22.2% in first-degree relatives.
Conclusions:
- Pityriasis versicolor inheritance is likely multifactorial, involving both genetic and environmental factors.
- Genetic predisposition plays a significant role, with substantial heritability observed in close relatives.
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