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Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes

  • 0Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
Cell Reports +

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May 28, 2025

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May 28, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Brain-machine interfaces (BMIs) can deliver instructions via intracortical microstimulation (ICMS). Monkeys learned instructions in the anterior intraparietal area (AIP), ventral premotor cortex (PMv), and primary somatosensory cortex (S1), but not dPPC or PMd.

Area Of Science

  • Neuroscience
  • Brain-Computer Interfaces
  • Motor Control

Background

  • Bidirectional brain-machine interfaces (BMIs) typically decode movement intent from the motor cortex and provide feedback to the primary somatosensory cortex (S1).
  • Parietal and premotor areas, unlike S1, encode complex movement-related information, suggesting potential for richer BMI feedback.
  • Investigating alternative cortical targets for BMI information delivery is crucial for advancing neuroprosthetic capabilities.

Purpose Of The Study

  • To determine if instructions for a center-out task can be effectively delivered via intracortical microstimulation (ICMS) to various cortical association areas.
  • To compare the efficacy of ICMS in the anterior intraparietal area (AIP), dorsal posterior parietal cortex (dPPC), dorsal premotor cortex (PMd), ventral premotor cortex (PMv), and S1 as targets for BMI feedback.

Main Methods

  • Two monkeys were trained on a center-out task using ICMS to deliver task instructions.
  • ICMS was applied to distinct cortical regions: AIP, dPPC, PMd, PMv, and S1.
  • Behavioral learning was assessed to determine successful instruction delivery and task acquisition.

Main Results

  • Monkeys successfully learned to interpret and act upon ICMS instructions delivered to the AIP, PMv, and S1.
  • Task acquisition was not achieved when ICMS instructions were delivered to the dPPC or PMd.
  • This indicates differential effectiveness of cortical areas as targets for BMI information.

Conclusions

  • The AIP, PMv, and S1 represent viable cortical territories for delivering task-relevant information through ICMS in BMIs.
  • The dPPC and PMd appear less effective for direct instruction delivery via ICMS compared to AIP, PMv, and S1.
  • Findings suggest optimizing BMI feedback strategies by targeting specific, more receptive cortical areas for enhanced performance.

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