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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Emerging Strategies for Drug-Based Cancer Risk Reduction.

Maria Daca-Álvarez1, Angelo Brunori1, Alessio Carbone2

  • 1Department of Gastroenterology, Hospital Clínic Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain.

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Summary
This summary is machine-generated.

Chemoprevention strategies are advancing to reduce cancer incidence. This review highlights novel approaches in breast, colorectal, and prostate cancer, emphasizing precision medicine for better outcomes.

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Area of Science:

  • Oncology
  • Preventive Medicine
  • Pharmacology

Background:

  • Chemoprevention utilizes pharmacologic agents to interrupt carcinogenesis and reduce cancer incidence.
  • Obesity is an increasingly prevalent risk factor for various cancers.
  • Hereditary cancer syndromes, like familial adenomatous polyposis, present unique challenges for chemoprevention.

Purpose of the Study:

  • To review emerging insights and recent advancements in chemoprevention across multiple cancer types.
  • To evaluate novel chemopreventive strategies, including optimized endocrine therapy for breast cancer and glucagon-like peptide-1 receptor agonists for obesity-related cancers.
  • To discuss the role of 5-alpha reductase inhibitors in prostate cancer prevention and chemopreventive approaches for hereditary colorectal cancer.

Main Methods:

  • Literature review of recent advancements in chemoprevention.
  • Analysis of novel therapeutic targets and agents.
  • Evaluation of evidence supporting specific chemopreventive agents in breast, colorectal, and prostate cancers.

Main Results:

  • Optimized endocrine therapy dosing enhances adherence and efficacy in breast cancer prevention.
  • Glucagon-like peptide-1 receptor agonists show potential in mitigating obesity-related cancer risks.
  • 5-alpha reductase inhibitors are effective and safe for prostate cancer incidence reduction.

Conclusions:

  • Precision medicine approaches are crucial for balancing chemoprevention efficacy, safety, and quality of life.
  • Targeted research and clinical trials are essential for advancing chemopreventive strategies.
  • Personalized chemoprevention holds significant promise for reducing cancer burden and improving patient outcomes.