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Updated: Sep 20, 2025

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
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Mitotic signalling in progenitor cells: Integrating cell division with cell specification

Torcato Martins1, Yuu Kimata2

  • 1Department of Medical Sciences, Institute of Biomedicine, University of Aveiro, Aveiro, Portugal.

Current Opinion in Cell Biology
|May 28, 2025
PubMed

Insights

Cell cycle regulators (CCRs) coordinate cell division and development. Recent advances reveal CCRs

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Molecular Biology

Background:

  • Cell cycle regulators (CCRs) are crucial for cell division and fate specification in metazoans.
  • CCRs utilize post-translational modifications for dynamic cell cycle control, ensuring unidirectional progression and integration with developmental cues.

Purpose of the Study:

  • To review recent findings on the noncanonical functions of CCRs, especially in progenitor cells.
  • To highlight how advanced technologies provide new insights into CCR mechanisms.

Main Methods:

  • Quantitative in vivo imaging
  • Precise genome editing
  • Single-cell omics technologies

Main Results:

  • CCRs regulate asymmetric cell division, epigenetic modifications, and cell cycle variations.
  • New technologies offer high spatiotemporal resolution into CCR functions.
  • The evolution of CCRs demonstrates their role in integrating cellular and developmental signals.

Conclusions:

  • CCRs play a vital role in multicellular organism development.
  • Understanding CCRs has implications for disease mechanisms and therapeutic strategies.

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