Evaluating the association between knee osteoarthritis severity and descending genicular artery caliber
Fardad Behzadi1, Bilal Siddiq2, Zhou Lan3
1Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Introduction:
Genicular artery embolization (GAE) is performed with the intent of reducing a pathologic increase of neovascularity in patients with osteoarthritis (OA) related knee pain. It is unclear whether knee OA is associated with upstream changes in genicular artery caliber. The purpose of this study was to evaluate the relationship between knee OA severity and descending genicular artery (DGA) caliber.
Materials And Methods:
A retrospective review of lower extremity computed tomographic (CT) angiography studies from July 2022 to March 2023 was conducted. Patients with Kellgren-Lawrence (KL) grade 0-4 knee OA were included. The caliber of the descending genicular artery (DGA) and the superficial femoral artery (SFA) at the level of the DGA origin were measured.
Results:
In the left and right leg respectively, a strong positive correlation was demonstrated between KL grade and DGA caliber (r = 0.68, p < 0.01), (r = 0.59, p < 0.01), and KL grade and DGA/SFA caliber (r = 0.71, p < 0.01), (r = 0.59, p < 0.01). No significant association was demonstrated between SFA caliber and KL grade in the right and left leg, respectively.
Discussion:
This retrospective study reveals significant positive correlations between the severity of knee OA, and caliber of the DGA. These findings suggest that joint level changes of OA may be associated with upstream changes in genicular artery caliber.
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