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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Sep 20, 2025

Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
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Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors

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Dual-targeting chemoimmunotherapy co-delivery system based on self-assembly and core-shell structure.

Yifei Guo1, Lijuan Ding1, Xiaoxue Lang1

  • 1State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151 Malianwa North Road, Haidian District, Beijing 100193, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 28, 2025
PubMed
Summary

This study developed dual-targeting nanoparticles for chemo-immunotherapy, enhancing breast cancer treatment. The novel system significantly boosted antitumor efficacy compared to conventional chemotherapy.

Keywords:
Breast cancerCo-delivery nanoparticlesCore-shell structureDual-targetingSelf-assembly property

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Mitochondria-mediated apoptosis is a key anti-tumor strategy.
  • Enhancing anti-tumor efficacy requires improved drug delivery systems targeting both cancer cells and mitochondria.
  • Chemo-immunotherapy offers a promising approach for breast cancer treatment.

Purpose of the Study:

  • To develop a dual-targeting co-delivery system for chemo-immunotherapy of breast cancer.
  • To combine celastrol (CEL), resiquimod (R848), and targeting ligands for enhanced anti-tumor effects.
  • To evaluate the efficacy of the developed nanoparticles in a preclinical breast cancer model.

Main Methods:

  • Self-assembly of celastrol, resiquimod, and triphenylphosphine into core nanoparticles (TCR).
  • Decoration of TCR nanoparticles with hyaluronic acid to form H/TCR NPs with dual targeting.
  • Characterization of nanoparticle size, structure, and stability.
  • In vivo evaluation in a 4T1 tumor-bearing mouse model.

Main Results:

  • H/TCR NPs exhibited a uniform core-shell structure (~164 nm) with good stability.
  • The nanoparticles demonstrated enhanced accumulation in mitochondria due to triphenylphosphine targeting.
  • Significant tumor inhibition (66.5%) was observed, outperforming paclitaxel.
  • The dual-targeting system effectively promoted celastrol's anti-tumor activity via mitochondria-mediated apoptosis.

Conclusions:

  • Co-delivery nanoparticles with dual targeting capabilities show combined anti-tumor effects.
  • The H/TCR NPs present a promising strategy for breast cancer chemo-immunotherapy.
  • This approach holds potential for addressing unmet needs in breast cancer treatment and overcoming drug resistance.