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Updated: May 14, 2026
Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
Published on: March 23, 2022
Progress in the application of organoids for exploring the relationship between macrophages and various lung diseases
Jiawang Wu1,2, Ting Liu1,2, Xinting Zhang1
1Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Yunnan Medical University, Key Laboratory of Respiratory Disease Research of Department of Education of Yunnan Province, Kunming 650021, People's Republic of China.
Abstract:
Organoids culturedex vivomimicin vivotissue and organ characteristics. They have become a focus in research for their potential in modeling macrophage function in respiratory diseases, offering insights into disease mechanisms and therapeutic strategies. A number of studies have confirmed organoids' utility in dissecting microbial interactions, disease modeling, genetic manipulation, and high-throughput drug screening for efficacy and safety. This review summarizes the research progress on organoids in exploring macrophage involvement in pulmonary diseases.
