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Air pollution is the risk factor for psychiatric disorders: a two-step Mendelian randomization study

Jingying Zhou1, Zhe Lu2, Ke Xu2

  • 1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China; School of Nursing, Peking University, Beijing 100191, China.

Journal of Affective Disorders
|May 28, 2025
PubMed
Summary

Air pollution, including fine particulate matter (PM2.5) and nitrogen dioxide (NO2), is genetically linked to psychiatric disorders like major depressive disorder and autism spectrum disorder. Brain imaging phenotypes mediate or mask these complex relationships.

Keywords:
Air pollutionBrain imagingMediation effectsMendelian randomization analysisPsychiatric disorders

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