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Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
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Liposomal formulations for waterproofing mucosal membranes.

Luisa Coderch1, Lucia Ricci2, Meritxell Martí3

  • 1Surfactants and Nanobiotechnology Department, Institute of Advanced Chemical of Catalonia of CSIC, (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|May 28, 2025
PubMed
Summary

Liposomes using stratum corneum lipids reinforce oral mucosa barrier function, significantly reducing permeation of drugs and a virus model. Ceramides play a key role in this enhanced barrier effect.

Keywords:
CeramidesLanolinMucosaPenetrationPermeation kineticsProtection

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Area of Science:

  • Biomaterials Science
  • Dermal Pharmacology
  • Drug Delivery Systems

Background:

  • Mucosal permeability is crucial for barrier function, influenced by specific lipids.
  • Stratum corneum lipids share similarities with lanolin, offering potential for barrier enhancement.
  • Liposomal formulations can decrease mucosal permeability.

Purpose of the Study:

  • To reinforce the oral mucosa barrier using liposomal formulations.
  • To decrease the permeation of active substances through the oral mucosa.
  • To evaluate the efficacy of ceramide- and lanolin-based liposomes.

Main Methods:

  • Liposomes were formulated using stratum corneum lipids (ceramides) or lanolin.
  • Transmembrane water loss was assessed for both liposomal formulations.
  • Permeation of caffeine, lidocaine, ketoprofen, ivermectin, and a virus model was evaluated on modified mucosa.

Main Results:

  • Both ceramide and lanolin liposomes significantly reduced transmembrane water loss.
  • A consistent permeation pattern was observed: caffeine > lidocaine > ketoprofen > ivermectin.
  • Ceramide-based liposomes were most effective in reducing permeation for all tested substances and the virus model.
  • Lanolin's effect on water loss did not translate to reduced drug permeation.

Conclusions:

  • Ceramides are crucial for the barrier function against drug and virus permeation.
  • Strengthening mucosal barrier function with liposomes can prevent or reduce permeation of various actives.
  • This approach has potential applications for blocking harmful agents like viruses, pollutants, and toxins.