Liposomal formulations for waterproofing mucosal membranes.

Area of Science:

• Biomaterials Science
• Dermal Pharmacology
• Drug Delivery Systems

Background:

• Mucosal permeability is crucial for barrier function, influenced by specific lipids.
• Stratum corneum lipids share similarities with lanolin, offering potential for barrier enhancement.
• Liposomal formulations can decrease mucosal permeability.

Purpose of the Study:

• To reinforce the oral mucosa barrier using liposomal formulations.
• To decrease the permeation of active substances through the oral mucosa.
• To evaluate the efficacy of ceramide- and lanolin-based liposomes.

Main Methods:

• Liposomes were formulated using stratum corneum lipids (ceramides) or lanolin.
• Transmembrane water loss was assessed for both liposomal formulations.
• Permeation of caffeine, lidocaine, ketoprofen, ivermectin, and a virus model was evaluated on modified mucosa.

Main Results:

• Both ceramide and lanolin liposomes significantly reduced transmembrane water loss.
• A consistent permeation pattern was observed: caffeine > lidocaine > ketoprofen > ivermectin.
• Ceramide-based liposomes were most effective in reducing permeation for all tested substances and the virus model.
• Lanolin's effect on water loss did not translate to reduced drug permeation.

Conclusions:

• Ceramides are crucial for the barrier function against drug and virus permeation.
• Strengthening mucosal barrier function with liposomes can prevent or reduce permeation of various actives.
• This approach has potential applications for blocking harmful agents like viruses, pollutants, and toxins.