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Related Concept Videos

Case Studies01:22

Case Studies

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There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
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Related Experiment Video

Updated: May 5, 2026

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
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Monitoring Methods for Monoamniotic Twin Pregnancies: Multicenter Retrospective Study of 149 Cases.

Norbert Winer1,2, Louise Cariou De Vergie1, Laure Maillet Dumas1

  • 1Department of Gynecology and Obstetrics, University Hospital, Nantes, France.

American Journal of Perinatology
|May 28, 2025
PubMed
Summary

Management strategies for monoamniotic twins, including inpatient versus outpatient care and delivery timing, showed no significant differences in perinatal mortality. This suggests flexibility in managing these rare, high-risk pregnancies.

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Area of Science:

  • Maternal-Fetal Medicine
  • Neonatology
  • Obstetrics

Background:

  • Monoamniotic twins are rare and carry a high risk of perinatal morbidity and mortality.
  • Specific complications like cord entanglement further worsen the prognosis for monoamniotic twins.
  • Optimal gestational age for birth and delivery mode remain subjects of debate in medical literature.

Purpose of the Study:

  • To evaluate the prenatal and intrapartum management strategies for monoamniotic twin pregnancies in France.
  • To compare outcomes between inpatient and outpatient management of monoamniotic twin pregnancies.
  • To analyze the impact of different management approaches on intrauterine and perinatal mortality rates.

Main Methods:

  • A retrospective, multicenter study involving 149 monoamniotic twin pregnancies across 10 French university hospitals over 18 years.
  • Comparison of inpatient versus outpatient follow-up strategies using propensity score matching.
  • Analysis of two gestational age groups: 26 0/7 to 34 6/7 weeks and post-35 weeks.

Main Results:

  • No significant difference in perinatal mortality rates between inpatient (15.8%) and outpatient (14.8%) management.
  • Overall fetal and neonatal mortality rates were similar for both inpatient (9.2%) and outpatient (9.2%) groups.
  • 33% of pregnancies continued past 35 weeks with a low rate of intrauterine death (1.5% after 35 weeks).

Conclusions:

  • Inpatient and outpatient management of monoamniotic twins yield comparable outcomes regarding perinatal mortality.
  • Continuing pregnancies past 35 weeks may be a viable option in select cases.
  • While cesarean delivery is common, vaginal delivery is not strictly contraindicated for monoamniotic twins.