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Restraining the killers: regulation of T cell quiescence
Molly E Lumnitzer1, Scott A Lovell1, Stephanie A Condotta1
1Department of Microbiology and Immunology, Indiana University Cooperative Center of Excellence in Hematology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
None:
Active regulation of T cell quiescence is important to sustain immune responses to vaccination and infection while preventing inappropriate responses such as autoimmunity. Recent studies highlight that quiescence in naïve T cells is actively regulated by transcription factors and tonic signaling. Loss of quiescence in aged T cells has significant consequences because the cells are less responsive to infection or vaccination. This review covers the current state of knowledge about transcriptional regulation of naïve T cell quiescence and how quiescence is lost in aged hosts and during chronic infection. Finally, we discuss the need for a deeper understanding of the factors involved in cell quiescence to identify targets to restore cell quiescence in dysfunctional T cells.
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