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Area of Science:

  • Oncology
  • Microbiology
  • Cancer Research

Background:

  • Intratumoral microbiota, particularly tumor-resident bacteria (TRB), are present in various cancers.
  • TRB interact with the tumor microenvironment (TME), playing a dual role in promoting or suppressing cancer.
  • Their functional roles and interactions necessitate multimodal technologies for comprehensive understanding.

Purpose of the Study:

  • To review current knowledge on TRB and their impact on cancer biology.
  • To discuss the origins, functions, and implications of TRB in cancer development, metastasis, immune modulation, and therapy response.
  • To explore bacteria-based therapeutic strategies and analytical challenges.

Main Methods:

  • Review of recent scientific literature on intratumoral microbiota and TRB.
  • Synthesis of findings on TRB's role in cancer development, metastasis, immune response, and treatment.
  • Discussion of multimodal technologies for TRB analysis and potential therapeutic interventions.

Main Results:

  • TRB are critical regulators of cancer biology with significant roles in tumor progression and metastasis.
  • TRB influence immune responses within the TME and affect patient responses to cancer therapies.
  • Modulating TRB presents a promising avenue for novel cancer treatment strategies.

Conclusions:

  • TRB are key players in cancer, influencing multiple facets of the disease.
  • Further research using advanced technologies is crucial to fully elucidate TRB functions and interactions.
  • Targeting TRB offers potential for innovative cancer therapies, though challenges in detection and analysis remain.