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Ethnicity modifies the association between microRNA single nucleotide polymorphisms and pediatric acute lymphoblastic

Sharon Benita Antony1, Julius Xavier Scott2, Indhumathi Nagarthinam3

  • 1Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.

Biomarkers in Medicine
|May 29, 2025
PubMed
Abstract

Insights

This meta-analysis investigated microRNA single nucleotide polymorphisms (miRNA-SNPs) and pediatric acute lymphoblastic leukemia (ALL) risk. While overall results were inconclusive, country-specific analyses suggest ethnicity-based differences in miRNA-SNP associations with ALL.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • MicroRNA (miRNA) single nucleotide polymorphisms (miRNA-SNPs) are implicated in various cancers.
  • Previous studies on miRNA-SNPs and pediatric acute lymphoblastic leukemia (ALL) have yielded inconsistent results.
  • A comprehensive meta-analysis is needed to clarify the association between miRNA-SNPs and pediatric ALL risk.

Purpose of the Study:

  • To perform a meta-analysis to statistically evaluate the association between miRNA-SNPs and pediatric ALL risk.
  • To investigate potential country-specific differences in this association using various genetic models.

Main Methods:

  • A systematic literature search was conducted on PubMed and Google Scholar for articles published between 2001 and 2023.
  • Meta-analysis was performed using MetaGenyo to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).
  • Subgroup analyses were conducted based on country-specific studies and different genetic models.

Main Results:

  • Data from 14 studies on four specific miRNA-SNPs (miR146 rs2910164, miR-196a2 rs11614913, miR-612 rs12803915, mir-499 rs3746444) were analyzed.
  • The overall pooled data analysis did not reveal a significant association between the studied miRNA-SNPs and pediatric ALL risk.
  • However, subgroup analyses showed significant country-specific variations in allele frequencies for all four miRNAs across different genetic models, suggesting ethnicity-based risk.

Conclusions:

  • The studied miRNA-SNPs, as a whole, did not show a statistically significant association with pediatric ALL risk in the overall meta-analysis.
  • Country-specific differences in allele frequencies highlight the potential role of ethnicity in miRNA-SNP associations with pediatric ALL.
  • MiRNA-SNPs warrant further investigation as potential risk factors in diverse populations.
Keywords:
EthnicityNOS scalegenetic modelsmeta-analysismetagenyomicroRNApediatric acute lymphoblastic leukemiasingle nucleotide polymorphism

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