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Effect of COMT Val158Met Polymorphism on Stroke Functional Outcome and Recovery.

Jiabin Liang1,2, Mingzhu Xu1,3, Xiaodong Wang1,4

  • 1Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, Teaching Affiliate of Harvard Medical School, Charlestown, MA, USA.

Neurorehabilitation and Neural Repair
|May 29, 2025
PubMed
Summary

The catechol-o-methyltransferase (COMT) Val158Met gene polymorphism is linked to better cognitive function and stroke recovery outcomes. Specifically, the COMT Met/Met genotype is associated with improved cognition, comprehension, and expression post-stroke.

Keywords:
COMTgenetic polymorphismoutcomerehabilitationstroke

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Area of Science:

  • Neuroscience
  • Genetics
  • Rehabilitation Medicine

Background:

  • The catechol-o-methyltransferase (COMT) gene, specifically the Val158Met single nucleotide polymorphism (SNP), is known to influence general cognitive function.
  • The role of this COMT Val158Met SNP in stroke recovery remains largely unexplored.
  • Understanding genetic factors like COMT Val158Met may offer insights into personalized stroke rehabilitation strategies.

Purpose of the Study:

  • To investigate the association between the COMT Val158Met (rs4680) SNP and functional outcomes in stroke survivors.
  • To determine if specific COMT genotypes correlate with cognitive function, comprehension, expression, and overall recovery after stroke.
  • To evaluate the impact of the COMT Val158Met polymorphism on functional independence post-stroke rehabilitation.

Main Methods:

  • A retrospective study analyzing data from 570 stroke patients with available genomic data from the MGB Biobank.
  • A subset of 164 patients admitted to Spaulding Rehabilitation Hospital (SRH) for inpatient rehabilitation was selected for detailed analysis.
  • Functional Independent Measures (FIM) were assessed at admission and discharge, with logistic and linear regression models used to evaluate the association between COMT Val158Met genotype and functional outcomes, adjusting for covariates.

Main Results:

  • Genotype analysis revealed a higher frequency of the COMT Met/Met genotype in patients with high cognitive functional outcomes.
  • After adjusting for covariates, the COMT Met/Met genotype was significantly associated with positive cognitive outcomes (P=0.029), including improved comprehension (P=0.013) and expression (P=0.007).
  • Independence dichotomization analysis showed that COMT Met/Met was linked to better outcomes in comprehension (P=0.002), expression (P=0.03), problem-solving (P=0.02), and memory (P=0.039).

Conclusions:

  • Stroke patients carrying the COMT Met/Met genotype demonstrated improved cognitive function, comprehension, and expression.
  • The COMT Val158Met polymorphism may serve as a potential genetic biomarker for predicting stroke recovery and cognitive outcomes.
  • These findings highlight the importance of considering genetic variations in the development of tailored stroke rehabilitation programs.