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Clinical Features and Current Therapeutic Approaches to Monilethrix: A Systematic Review
Adam C Yu1, Dana Koroluk1, Fatmah Alzahrani2
1Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Monilethrix, a rare genetic hair disorder, shows best treatment response with topical and oral minoxidil. Further pediatric studies are needed for long-term outcomes and new therapies for beaded hair.
Area of Science:
- Genetics and Dermatology
- Pediatric Health
- Rare Disease Research
Background:
- Monilethrix is a rare congenital hair disorder.
- Characterized by fragile, beaded hair shafts.
- Caused by mutations in keratin or desmoglein 4 genes.
Conclusions:
- Minoxidil shows promise as a primary treatment for Monilethrix.
- Long-term outcomes and novel therapeutic strategies require further investigation.
- Pediatric clinical studies are essential for advancing Monilethrix management.
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