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Updated: Jan 6, 2026

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
04:01

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

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Sepsis-induced cardiomyopathy

Nadia Aissaoui1, Florence Boissier2, Michelle Chew3

  • 1Department of Cardiology, Georges Pompidou Hospital, Université Paris Cité, 20-25 rue Leblanc, 75015 Paris, France.

European Heart Journal
|May 29, 2025
PubMed

Insights

Sepsis-induced cardiomyopathy (SICM) is a common, reversible heart dysfunction in critically ill patients. Understanding SICM

Area of Science:

  • Critical Care Medicine
  • Cardiology
  • Sepsis Research

Background:

  • Sepsis is a leading cause of death globally and a frequent diagnosis in CCUs.
  • Sepsis-induced cardiomyopathy (SICM) is a recognized cardiac complication of sepsis.
  • SICM is characterized by reversible ventricular dysfunction unrelated to coronary artery disease.

Purpose of the Study:

  • To review current knowledge on SICM epidemiology, pathophysiology, and clinical presentation.
  • To provide insights for optimizing the management of patients with SICM.
  • To enhance understanding of SICM's course and implications for improved clinical outcomes.

Main Methods:

  • Literature review of existing studies on sepsis-induced cardiomyopathy.
  • Synthesis of epidemiological data.
  • Analysis of pathophysiological mechanisms and clinical manifestations.

Main Results:

  • SICM is a common, reversible condition in sepsis patients.
  • It involves acute systolic and/or diastolic dysfunction of one or both ventricles.
  • Current management focuses on restoring tissue perfusion.

Conclusions:

  • A comprehensive understanding of SICM is crucial for effective patient management.
  • Optimizing interventions based on SICM insights can improve outcomes.
  • Further research into SICM's course and implications is warranted.

Keywords:
New-onset LV systolic dysfunctionSepsisSepsis-induced cardiomyopathy

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