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Short Anagen Hair Syndrome and Its Association With WNT10A Gene Variants: A Report of Three Pediatric Cases
Nelly Marlene Román Mendoza1, Magdalini Louka1, Sergio García-González1
1Department of Dermatology, Hospital Infantil Universitario Niño Jesus, Madrid, Spain.
Abstract:
Short anagen hair syndrome (SAHS) is a rare hair disorder characterized by a shortened anagen phase, limiting hair growth to a few centimeters. SAHS is a benign condition often improving after puberty, with diagnosis supported by clinical, trichological, and genetic findings. We report three pediatric cases of persistently short hair, all with negative hair pull tests and trichogram findings revealing club-shaped roots, tapering, and hair shaft diameter variability. Genetic testing identified the c.682 T>A;p.(Phe228Ile) variant in heterozygosity in the WNT10A gene in two patients, a variant reported as a risk factor for the condition.
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