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Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

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Related Experiment Video

Updated: Sep 20, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Published on: June 1, 2012

Naturally Derived Biomaterial-Based Microneedles With Microenvironment-Response Potential for Diabetic Wound Healing.

Xu Gong¹, Zong-Lin Li², Rui-Peng Cai^1,3

¹Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [And] the European Tissue Repair Society

|May 29, 2025

Summary

Naturally derived microneedles offer a minimally invasive solution for diabetic wound healing. These advanced biomaterials adapt to wound microenvironments, improving therapeutic delivery and promoting faster recovery.

Keywords:

diabetic wound healing microenvironment microneedles natural biomaterials

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Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing Research

Background:

Diabetic patients frequently experience delayed wound healing due to complex wound pathophysiology and hostile microenvironments.
Developing effective treatments for non-healing diabetic wounds remains a significant clinical challenge.

Purpose of the Study:

To review the design, development, and mechanisms of naturally derived biomaterial-based microneedles for diabetic wound healing.
To discuss microenvironment-responsive microneedle strategies and their translational implications.

Main Methods:

Review of current literature on naturally derived biomaterial microneedles for wound treatment.
Analysis of microneedle design principles and drug delivery capabilities.
Examination of mechanisms by which microneedles interact with diabetic wound microenvironments.

Main Results:

Naturally derived microneedles show excellent biocompatibility, biodegradability, and low toxicity.
These microneedles enhance healing by providing mechanical support and delivering therapeutic agents like antimicrobials, growth factors, and antioxidants.
Microenvironment-responsive microneedles demonstrate improved efficacy in diabetic wound treatment.

Conclusions:

Naturally derived biomaterial microneedles represent a promising minimally invasive approach for diabetic wound healing.
Further development and interdisciplinary collaboration are crucial for translating these innovations into clinical practice.
Microenvironment-responsive microneedle technology holds significant potential for improving patient outcomes in diabetic wound management.