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Related Experiment Video

Updated: Jun 17, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

Emerging in vivo tools for ILC2 research.

Timotheus Y F Halim¹

¹Cancer Research UK - Cambridge Institute, Li Ka Shing Centre, University of Cambridge , Cambridge, UK.

The Journal of Experimental Medicine

|May 29, 2025

Summary

Researchers developed a new mouse model to investigate the function of Rora in group 2 innate lymphoid cells (ILC2), which are key to immune responses and tissue health.

Area of Science:

Immunology
Cell Biology
Genetics

Background:

Group 2 innate lymphoid cells (ILC2) are crucial for regulating inflammation and maintaining tissue homeostasis.
Understanding ILC2 function is vital for numerous physiological and pathological processes.
Mouse models are essential tools for studying ILC2 biology.

Purpose of the Study:

To develop a novel mouse model for studying the role of Rora in mature ILC2.
To enable targeted investigation of gene function within specific ILC2 populations.

Main Methods:

Development of a novel Il17rbCreERT2.eGFP reporter mouse.
Utilizing Cre-lox technology for lineage tracing and gene manipulation in ILC2.
Characterization of ILC2 populations and their function in the developed mouse model.

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Main Results:

The Il17rbCreERT2.eGFP mouse model allows for specific targeting of mature ILC2.
This model facilitates the study of transcription factors, such as Rora, within ILC2.
Initial findings support the utility of this model for dissecting ILC2-specific mechanisms.

Conclusions:

The novel Il17rbCreERT2.eGFP mouse model is a valuable tool for advancing research into ILC2 biology.
This model will aid in understanding the specific roles of genes like Rora in ILC2-mediated functions.
Future studies using this model will enhance our knowledge of inflammation and tissue homeostasis.