A Paper Strip-Based Photoinduced Electrogenerated Chemiluminescence Platform with CTF/PMo12 Heterojunction-Sensitive...

Area of Science:

• Electrochemistry
• Chemiluminescence
• Materials Science

Background:

• Glutamic acid (GA) is a vital neurotransmitter implicated in brain function and neurological disorders.
• Elevated GA levels correlate with conditions like stroke, Parkinson's, epilepsy, and Alzheimer's disease.
• Accurate GA detection is crucial for diagnosis and research.

Purpose of the Study:

• To develop a sensitive and selective photoinduced electrogenerated chemiluminescence (PECL) test strip for glutamic acid detection.
• To integrate the PECL system with smartphone technology for on-site, real-time monitoring.
• To validate the method's safety and feasibility for biological samples.

Main Methods:

• Fabrication of a test strip fiber paper using a covalent triazine framework (CTF)/polyoxometalate (PMo12) heterojunction.
• Utilizing blue-light irradiation and an electric field to drive PECL reactions based on luminol oxidation for GA detection.
• Employing smartphone-based fluorometry to capture PECL signals and RGB values.

Main Results:

• Achieved sensitive detection of GA within a linear range of 0.05-1.7 mM.
• Established a low limit of detection (LOD) of 15 nM for GA.
• Demonstrated satisfactory selectivity for GA detection in biological samples.

Conclusions:

• The PECL test strip offers a safe, feasible, and sensitive method for GA detection.
• Smartphone integration enables on-site, visual, real-time monitoring.
• This approach is suitable for high-throughput point-of-care testing and disease monitoring.