Murine monoclonal antibodies which recognize adenosine deaminase from calf, mouse, rat and man

Three monoclonal antibodies against calf adenosine deaminase were obtained from mice. All three strongly cross-react with the rat and human forms of adenosine deaminase, and two of them with the mouse enzyme. We show that these reagents can be useful for the preparation of adenosine deaminase-free cell culture media and consider their potential interest for the early immunofluorescence detection of T-cell acute lymphoblastic leukemias.