Related Experiment Video
Updated: Aug 15, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
The formation of immune complexes in primiparous and multiparous human pregnancies
Abstract:
Using a recently developed ELISA, antibodies were detected in maternal sera with reactivity directed against determinants present on the plasma membrane of the outer layer of the placenta, the syncytiotrophoblast. The anti-trophoblast antibodies were present in maternal sera in the form of "free" antibodies and "immune complex" antibodies. Examination of the sera throughout gestation and from successive pregnancies revealed that the generation of anti-trophoblast antibodies and the formation of immune complexes was predominantly a first pregnancy and early second pregnancy event, with very little activity detectable in later pregnancies. It is proposed that immune recognition occurs in a first pregnancy, which generates some form of immunosuppression that involves the activation of suppressor memory cells.
Related Concept Videos
Humoral Immune Responses
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Immunoprecipitation
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...
Teratogenicity
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Hypersensitivity Reactions: Immune-Complex Reactions

