Related Experiment Video
Updated: Jan 18, 2026
Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
Initial Subjective Response to Nicotine Vaping Predicts Subsequent E-Cigarette Use in Early Adolescence: An ABCD
Kelly E Courtney1, Tam T Nguyen-Louie1, Wesley K Thompson1,2,3
1Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Introduction:
Differences in sensitivity to substances are important for understanding variability in addiction propensity. The value of modeling subjective response to nicotine, particularly e-cigarettes, at first use as a predictor of future use remains largely untested.
Methods:
This secondary analysis of the Adolescent Brain Cognitive Development (ABCD) Study data included 147 youth (51% female; mean age = 13 at first assessment) who reported vaping of an e-cigarette and provided their subjective response to that experience during the 4 years of baseline and annual follow-up data currently available. Analyses evaluated the longitudinal relationships between subjective response to vaping and subsequent annual e-cigarette episodes (ie, quantity) and use days (ie, frequency) using semi-parametric Bayesian mixture models. Effects were estimated at quantiles (25th, 50th, and 75th) of the e-cigarette use outcomes, representing lower, average (ie, median), and higher use.
Results:
Greater pleasurable sensations to vaping at first use predicted greater past-year e-cigarette use for all participants, with youth endorsing higher use exhibiting stronger relationships (bLower use = 0.07-0.10; bMedian use = 0.37-0.75; bHigher use = 22.3-61.4). Greater initial unpleasant sensations to vaping also predicted greater subsequent use (bLower use = 0.16-0.19; bMedian use = 0.54-0.74). Among youth endorsing higher use, unpleasant subjective response was associated with future use quantity (b = 22.00), but not frequency.
Conclusions:
These findings suggest that initial subjective response to nicotine vaping in youth is a strong predictor of e-cigarette use behavior up to 4 years later, particularly in those endorsing higher use. This knowledge can be used to enhance early prevention efforts to reduce e-cigarette use in this vulnerable population.
Implications:
This study advances the initial subjective response to nicotine vaping in youth as a strong predictor of future e-cigarette use behavior, particularly in youth endorsing higher use. This knowledge can be used to help identify risk and protective factors for nicotine use, as well as enhance early prevention efforts to reduce e-cigarette use in this vulnerable population.
More Related Videos
08:39Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
09:30A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
Published on: January 18, 2018
Related Concept Videos
01:29Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
01:23Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...