Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individual Strategies and Institutional Solutions: Advancement of Asian Women in Academic Surgery.

The Journal of surgical research·2026
Same author

Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 Overexpression Abrogates ST6GAL1 Mediated Rectal Cancer Chemoradiation Resistance.

Cancer genomics & proteomics·2026
Same author

Normothermic Machine and Regional Perfusion in U.S. DCD Liver Transplantation: A National Comparative Analysis Supporting Adoption as Standard of Care.

Annals of surgery·2026
Same author

The Path to Independence: Progression in Entrustment Reflected in Entrustable Professional Activity Ratings.

Annals of surgery·2026
Same author

American Association of Endocrine Surgeons statement on clinical productivity and compensation for endocrine surgeons.

Surgery·2026
Same author

The CHRONO trial: Protocol for a randomized controlled trial of early time-restricted eating in patients with breast or rectal cancer.

Nutrition research (New York, N.Y.)·2026

Related Experiment Video

Updated: Sep 20, 2025

Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction
12:34

Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction

Published on: January 3, 2020

16.8K

Neoadjuvant Therapy Versus Upfront Surgery for Resectable and Borderline Resectable Pancreatic Cancer: A Systemic

Chandler A Annesi1, Michelle Holland1, M Chandler McLeod1

  • 1Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.

The Journal of Surgical Research
|May 29, 2025
PubMed
Summary

Neoadjuvant therapy (NAT) improved overall survival for pancreatic cancer patients compared to upfront surgery (UFS). However, this survival benefit was not observed in patients with resectable pancreatic cancer alone.

Keywords:
Borderline resectableMeta-analysisNeoadjuvant therapyPancreatic cancerResectableSystematic reviewUpfront surgery

More Related Videos

Laparoscopic Radical Left Pancreatectomy for Pancreatic Cancer: Surgical Strategy and Technique Video
10:04

Laparoscopic Radical Left Pancreatectomy for Pancreatic Cancer: Surgical Strategy and Technique Video

Published on: June 6, 2020

9.7K
Laparoscopic Radical Antegrade Modular Pancreatosplenectomy via Dorsal-Caudal Artery Approach for Pancreatic Neck-Body Cancer
12:07

Laparoscopic Radical Antegrade Modular Pancreatosplenectomy via Dorsal-Caudal Artery Approach for Pancreatic Neck-Body Cancer

Published on: November 18, 2022

4.0K

Related Experiment Videos

Last Updated: Sep 20, 2025

Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction
12:34

Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction

Published on: January 3, 2020

16.8K
Laparoscopic Radical Left Pancreatectomy for Pancreatic Cancer: Surgical Strategy and Technique Video
10:04

Laparoscopic Radical Left Pancreatectomy for Pancreatic Cancer: Surgical Strategy and Technique Video

Published on: June 6, 2020

9.7K
Laparoscopic Radical Antegrade Modular Pancreatosplenectomy via Dorsal-Caudal Artery Approach for Pancreatic Neck-Body Cancer
12:07

Laparoscopic Radical Antegrade Modular Pancreatosplenectomy via Dorsal-Caudal Artery Approach for Pancreatic Neck-Body Cancer

Published on: November 18, 2022

4.0K

Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Pancreatic cancer treatment typically combines surgery and chemotherapy, but the optimal sequence is debated.
  • Ongoing trials compare neoadjuvant therapy (NAT) versus upfront surgery (UFS) for resectable and borderline resectable pancreatic cancer.
  • New data analysis is crucial for understanding treatment sequencing benefits.

Purpose of the Study:

  • To systematically review and meta-analyze randomized controlled trials (RCTs).
  • To compare the overall survival (OS) outcomes of NAT versus UFS in pancreatic cancer patients.
  • To conduct subgroup analyses for resectable pancreatic cancer.

Main Methods:

  • Systematic search of multiple databases for relevant RCTs.
  • Meta-analysis performed according to PRISMA guidelines.
  • Random-effects models used for analysis, with OS as the primary outcome.

Main Results:

  • Ten RCTs involving 1340 patients were included.
  • NAT demonstrated a significant improvement in median OS compared to UFS (HR 0.78, P=0.04).
  • No significant OS improvement was found in the subgroup of patients with resectable pancreatic cancer (HR 0.86, P=0.36).

Conclusions:

  • NAT is associated with improved OS versus UFS in patients with resectable and borderline resectable pancreatic cancer.
  • The heterogeneity of NAT regimens and recruitment challenges necessitate further research.
  • Additional studies are required to confirm findings and optimize treatment sequencing.