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Updated: Jun 14, 2025

Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
Published on: October 27, 2023
The relationship between interleukin and ankylosing spondylitis
Zekai Zhu1, Haoran Wang2, Xiaotian Wang1
1Department of Orthopaedics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
Abstract:
Ankylosing spondylitis is an autoimmune rheumatic disease, the development and progression of which are inseparably linked to cytokines. In recent years, with the rise of cytokine research, the "star family" of cytokines-the interleukin family-has gradually emerged as a key player in ankylosing spondylitis. The interleukin family consists of 38 members, among which 11 members are directly involved in or indirectly reflect the disease course of ankylosing spondylitis.At present, the interleukins that have been most extensively studied for this disease are IL-6, IL-17, and IL-23. Meanwhile, the research on targeted therapy for this disease is also somewhat limited to these three interleukins. This review introduces the roles and mechanisms of relevant interleukins in ankylosing spondylitis and focuses on interleukin-targeted therapy for the disease, aiming to provide a theoretical reference for the development of new therapeutic targets.
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