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  11. Synergistic Enhancement Of Desferrioxamine And Strontium-doped Hydroxyapatite Via Coaxial Electrostatic Spinning On Osteogenic Differentiation

Synergistic enhancement of desferrioxamine and strontium-doped hydroxyapatite via coaxial electrostatic spinning on osteogenic differentiation

Yongman Liu1, Yubin Wang1, Wenxin Meng2

  • 1School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China.

Biomaterials Advances
|May 29, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Dual drug-releasing nanofibre membranes loaded with strontium-doped hydroxyapatite and desferrioxamine show promise for bone repair. These membranes enhance cell growth, blood vessel formation, and bone cell development by sustained drug release.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Defective bone repair presents significant clinical challenges, including donor site morbidity and graft limitations.
  • Artificial bone graft substitutes are under development, but achieving effective osteogenesis remains difficult.
  • Novel strategies are needed to improve bone regeneration and overcome current limitations.

Purpose of the Study:

  • To fabricate dual drug-releasing nanofibre membranes (NMs) for enhanced bone repair.
  • To investigate the synergistic effects of strontium-doped hydroxyapatite (SrHA) and desferrioxamine (DFO) on bone regeneration.
  • To evaluate the potential of these NMs in promoting osteogenesis and angiogenesis.

Main Methods:

  • Coaxial electrostatic spinning was employed to create nanofibre membranes.
Keywords:
DesferrioxamineElectrospun nanofiber membraneHydroxyapatiteOsteogenic differentiation

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  • Strontium-doped hydroxyapatite (SrHA) was loaded into the shell and desferrioxamine (DFO) into the core for controlled release.
  • The effects of DFO/SrHA NMs on rat bone mesenchymal stem cells (BMSCs) were assessed, focusing on proliferation, angiogenesis, and osteogenic differentiation.

    • Main Results:

    • DFO/SrHA NMs demonstrated sustained and slow release of both DFO and SrHA.
    • The NMs significantly promoted BMSC proliferation and angiogenesis.
    • Enhanced osteogenic differentiation of BMSCs was observed due to the synergistic action of DFO and SrHA.
    • Long-term activation of HIF-1α and Wnt/β-catenin signaling pathways was maintained.

    Conclusions:

    • Dual drug-releasing DFO/SrHA NMs offer a promising strategy for defective bone repair.
    • The synergistic effect of sustained DFO and SrHA release enhances osteogenic differentiation and angiogenesis.
    • These NMs represent a viable alternative to traditional bone grafting methods.
    Strontium