Study on the correlation between atmospheric pollutants and the development of IgA vasculitis

In recent years, a growing number of studies have shown an association between air pollution and the development of vasculitis. Therefore, in this study, we collected data on the monthly number of visits of patients with IgA vasculitis to the pediatric outpatient and inpatient clinics of the Second Central Hospital of Baoding City and the monthly average values of PM10, PM2.5, SO2, NO2, CO, and O3 in Baoding from January 2014 to December 2022. We correlated the monthly mean values of each air pollutant with the number of patients with IgA vasculitis per month using Spearman correlation analysis. The effect of different air pollutants on the number of IgA vasculitis cases was also analyzed using multiple linear regression analysis. We found that airborne concentrations of PM2.5, PM10, NO2, and CO were positively associated with the number of cases of IgA vasculitis, and airborne concentrations of O3 were negatively associated with IgA vasculitis. Among all air pollutants, NO2 has the greatest impact on the incidence of IgA vasculitis. So we thought there was a positive correlation between airborne NO2 and the development of IgA vasculitis.